Dr. Ci: Labo is a health and pharmaceutical company specializing in skincare products, founded in 1999 by Dr. Shio and launched in 2000 as a health supplement, beauty device, make-up, and body care product. After studying the data of 20,000 women over three years, Dr. Shio developed a miracle substance called “Gel.” Initially, it was only used by patients, but as consumers’ desire to buy increased, it gradually led to the commercialization of the Dr. Ci: Labo brand range of skincare products. In 2010, it achieved the top spot with 46% of all skin care sales in Japan. As new cosmetic companies continue to go public, Dr. Shiroyuki continues to move forward as a leader in the pharmaceutical cosmetics industry.